Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens.

@article{Adermark2011ImplicationsFG,
  title={Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens.},
  author={Louise Adermark and Rhona B. C. Clarke and Torsten Olsson and Elisabeth Hansson and Bo S{\"o}derpalm and Mia Ericson},
  journal={Addiction biology},
  year={2011},
  volume={16 1},
  pages={43-54}
}
Elevated dopamine levels are believed to contribute to the rewarding sensation of ethanol (EtOH), and previous research has shown that strychnine-sensitive glycine receptors in the nucleus accumbens (nAc) are involved in regulating dopamine release and in mediating the reinforcing effects of EtOH. Furthermore, the osmoregulator taurine, which is released from astrocytes treated with EtOH, can act as an endogenous ligand for the glycine receptor, and increase extracellular dopamine levels. The… CONTINUE READING
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The Authors, Addiction Biology © 2010 Society for the Study of Addiction

  • Louise Adermark
  • 2010

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