Implications for environmental health of multiple stressors

  title={Implications for environmental health of multiple stressors},
  author={Carmel Mothersill and Colin B. Seymour},
  journal={Journal of Radiological Protection},
  pages={A21 - A28}
Recent insights into the mechanisms underlying the biological effects of low dose effects of ionising radiation have revealed that similar mechanisms can be induced by chemical stressors in the environment. This means that interactions between radiation and chemicals are likely and that the outcomes following mixed exposures to radiation and chemicals may not be predictable for human health, by consideration of single agent effects. Our understanding of the biological effects of low dose… 

In Vivo Interactions between Ionizing Radiation, Inflammation and Chemical Carcinogens Identified by Increased DNA Damage Responses

The data demonstrate that exposure to ionizing radiation on two separate occasions ten days apart leads to an increase in the percentage of cells with a sub-G0 DNA content compared to cells exposed only once, and this is a greater than additive effect.

The radiobiology/radiation protection interface in healthcare

The current knowledge of radiation effects is reviewed and implications for its application in healthcare considered. The 21st L H Gray conference gathered leading experts in radiobiology, radiation

Low dose of uranium induces multigenerational epigenetic effects in rat kidney

The results confirm the importance of the developmental windows’ sensitivity in addition to the sexual dimorphisms of the offspring in order to distinguish the sexual differences and the developmental process that are critical windows for epigenetic effects over generations.

Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys

The results demonstrate that multiscale systems biology is useful in elucidating the most discriminative pathways from genomic to metabolomic levels for assessing the biological impact of this low-level environmental exposure, i.e. the exposome.

Uncomfortable issues in radiation protection posed by low-dose radiobiology

Issues are raised which suggest that low-dose effects are much more complex than has been previously assumed, including genomic instability, bystander effects, multiple stressor exposures and chronic exposures.

Understanding Low-Dose Exposure and Field Effects to Resolve the Field-Laboratory Paradox: Multifaceted Biological Effects from the Fukushima Nuclear Accident

  • J. Otaki
  • Physics, Environmental Science
  • 2018
Many reports about the biological effects of the Fukushima nuclear accident on vari - ous wild organisms have accumulated in recent years. Results from field-based labora tory experiments using the

Radiation-Induced Bystander Effects and Stress-Induced Mutagenesis

This chapter reviews knowledge of radiation-induced bystander effects, and how they may contribute to the authors' mechanistic understanding of mutagenesis and adaptive evolution, and implications for disease therapy, protection of species—including humans—from stressors such as radiation, and mechanisms of evolutionary change are discussed.

Radiation terrorism: what society needs from the radiobiology–radiation protection and radiation oncology communities

  • C. ColemanG. W. Parker
  • Medicine
    Journal of radiological protection : official journal of the Society for Radiological Protection
  • 2009
Optimal response must be based on the best available science and requires scientists who can define, prioritise and address the gaps in knowledge with the range of expertise from basic physics to biology to translational research to systems expertise to response planning to healthcare policy to communications.

Stress-associated radiation effects in pygmy wood mouse Apodemus uralensis (Muridae, Rodentia) populations from the East-Urals Radioactive Trace

The level of LPO, catalase activity, and DNA/protein ratio in the spleen and the total protein content in the adrenal glands were the most sensitive to the interaction of population size and radiation exposure.



Health Risks of Low Dose Ionizing Radiation in Humans: A Review

In this opinion, both the linear no-threshold-response and the threshold-response models might not be suitable in predicting cancer risk at low radiation doses in a quantitative sense.

Multiple stressors : a challenge for the future

This work focuses on the evaluation of the role of radioecotoxicology in the assessment of the impact of multiple stressors on the health of animals and human cells in the context of a multi-factorial environment.

Environmentally relevant mixed exposures to radiation and heavy metals induce measurable stress responses in Atlantic salmon.

The results, although complex, indicate that these stress signal responses may aid in the mechanistic investigation of mixed contaminant effects in fish exposed to metals and radiation.

Heavy metals of relevance to human health induce genomic instability

It is shown that cadmium and nickel can produce delayed effects in human cells in vitro, which are characteristic of genomic instability, even at levels where no acute toxic effects can be demonstrated.

Effects of hTERT on metal ion-induced genomic instability

The type of genomic instability in human cells may depend critically on whether they are telomerase-positive or -negative and that their sensitivities to metals could depend onWhether they are clustered or diffuse.

The effects of gamma rays on longevity

Data emerged suggesting that low dose rates/cumulative doses enhanced longevity in mice and guinea pigs of both sexes, and the average life span was enhanced by 10–30% but not the maximum life span potential.

ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation.

A model of neurodegeneration based upon the complexity of CNS functions is proposed, based upon evidence on the effects of an exogenous generator of ROS, ionizing radiation, in major population events with radionuclides.

Mechanism of radiation‐induced bystander effects: a unifying model

Bystander observations imply that the relevant target for various radiobiological endpoints is larger than an individual cell, and a better understanding of the cellular and molecular mechanisms of the bystander phenomenon will allow a more accurate model for assessing the health effects of low doses of ionizing radiation.