Implications for chronic toxicity of benzo[a]pyrene in sea bream cultured hepatocytes: Cytotoxicity, inflammation, and cancerogenesis.

@article{Santacroce2015ImplicationsFC,
  title={Implications for chronic toxicity of benzo[a]pyrene in sea bream cultured hepatocytes: Cytotoxicity, inflammation, and cancerogenesis.},
  author={Maria Pia Santacroce and Anna Selene Pastore and Antonella Tinelli and Michele Colamonaco and Giuseppe Di Crescenzo},
  journal={Environmental toxicology},
  year={2015},
  volume={30 9},
  pages={
          1045-62
        }
}
Benzo[a]pyrene (B[a]P) is the most studied dangerous polycyclic aromatic hydrocarbon for its hepatotoxic, carcinogenic, mutagenic, teratogenic, and immunosuppressant effects, which can affect both wild and farmed marine fish through the trophic chain. This study investigated, for the first time, the chronic effects induced in vitro by B[a]P prolonged exposure on gilthead sea bream (Sparus aurata L.) hepatocytes, evaluating the cellular and nuclear latent damage. The purpose was to characterize… CONTINUE READING
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