Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients.

@article{Gluck2002ImplicationsFA,
  title={Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients.},
  author={Martin R Gluck and Rohan G Thomas and Kenneth L. Davis and Vahram Haroutunian},
  journal={The American journal of psychiatry},
  year={2002},
  volume={159 7},
  pages={1165-73}
}
OBJECTIVE Pharmacological, clinical, and postmortem studies suggest altered gamma-aminobutyric acid (GABA)-ergic and glutamatergic function in patients with schizophrenia. The dorsolateral prefrontal cortex is one key locus of abnormality. The precise neurochemical mechanisms underlying neurotransmitter alterations, such as hypoglutamatergia or GABA dysfunction, are not well understood. This study investigated key biochemical elements of GABA and glutamate metabolism in brain specimens from… CONTINUE READING
33 Citations
62 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Functional and molecular dysregulation of GABA systems in DLPFC of schizophrenics

  • V Haroutunian, S Dracheva, SL Elhakem, MG Gluck, LJ Siever, KL Davis
  • Abstracts of the Society for Neuroscience
  • 2001
1 Excerpt

Similar Papers

Loading similar papers…