Implications for NKG 2 D-Mediated NK Cell Expression and Release in Leukemia : Comprehensive Analysis of NKG 2 D Ligand Steinle and

@inproceedings{Hilpert2012ImplicationsFN,
  title={Implications for NKG 2 D-Mediated NK Cell Expression and Release in Leukemia : Comprehensive Analysis of NKG 2 D Ligand Steinle and},
  author={Julia Hilpert and Ludger Grosse-Hovest and Frank Gruenebach and Corina Buechele and Tina Nuebling and Tobias Raum and Alexander Steinle and Helmut Rainer Salih},
  year={2012}
}
Ligands of the prototypical activating NK receptor NKG2D render cancer cells susceptible to NK cell-mediated cytolysis if expressed at sufficiently high levels. However, malignant cells employ mechanisms to evade NKG2D-mediated immunosurveillance, such as NKG2D ligand (NKG2DL) shedding resulting in reduced surface expression levels. In addition, systemic… CONTINUE READING