Implications and concepts of polyamine-nucleic acid interactions.

  title={Implications and concepts of polyamine-nucleic acid interactions.},
  author={Burt G. Feuerstein and Loren Dean Williams and Hirak S. Basu and Laurence J. Marton},
  journal={Journal of cellular biochemistry},
  volume={46 1},
Modeling, x-ray diffraction, and solution studies have contributed to the understanding of interactions between polyamines and nucleic acids. Polyamines stabilize a variety of unusual DNA structures and conformations in vitro, including both the left-handed Z and the right-handed A DNA. In addition, polyamines condense DNA and may be important in bending specific sequences. Investigations into the mechanisms of these effects provide support for both specific and nonspecific interactions between… CONTINUE READING