Implication of the purinergic system in alcohol use disorders.

  title={Implication of the purinergic system in alcohol use disorders.},
  author={Liana Asatryan and Hyung Wook Nam and Moonnoh Lee and Mahesh M Thakkar and M Saeed Dar and Daryl L Davies and Doo-Sup Choi},
  journal={Alcoholism, clinical and experimental research},
  volume={35 4},
In the central nervous system, adenosine and adenosine 5'-triphosphate (ATP) play an important role in regulating neuronal activity as well as controlling other neurotransmitter systems, such as, GABA, glutamate, and dopamine. Ethanol increases extracellular adenosine levels that regulate the ataxic and hypnotic/sedative effects of ethanol. Interestingly, ethanol is known to increase adenosine levels by inhibiting an ethanol-sensitive adenosine transporter, equilibrative nucleoside transporter… CONTINUE READING