Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis.

  title={Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis.},
  author={J C Lambert and Benjamin Grenier-Boley and Vincent Chouraki and Simon Heath and Diana Z{\'e}l{\'e}nika and Nathalie Fievet and Didier Hannequin and Florence Pasquier and Olivier Hanon and Alexis Brice and Jacques Epelbaum and C Berr and Jean-François Dartigues and Christophe Tzourio and Dominique Campion and Mark Lathrop and Philippe Amouyel},
  journal={Journal of Alzheimer's disease : JAD},
  volume={20 4},
The results of several genome-wide association studies (GWASs) in the field of Alzheimer's disease (AD) have recently been published. Although these studies reported in detail on single-nucleotide polymorphisms (SNPs) and the neighboring genes with the strongest evidence of association with AD, little attention was paid to the rest of the genome. However, complementary statistical and bio-informatics approaches now enable the extraction of pertinent information from other SNPs and/or genes… CONTINUE READING
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