Implication of ornithine acetyltransferase activity on l-ornithine production in Corynebacterium glutamicum.

@article{Hao2016ImplicationOO,
  title={Implication of ornithine acetyltransferase activity on l-ornithine production in Corynebacterium glutamicum.},
  author={Ning Hao and Jingrui Mu and Nan Hu and Sheng Xu and Peng Shen and Ming Yan and Yan Li and Lin Xu},
  journal={Biotechnology and applied biochemistry},
  year={2016},
  volume={63 1},
  pages={15-21}
}
l-Ornithine is an intermediate of the l-arginine biosynthetic pathway in Corynebacterium glutamicum. The effect of ornithine acetyltransferase (OATase; ArgJ) on l-ornithine production was investigated, and C. glutamicum 1006 was engineered to overproduce l-ornithine as a major product by inactivating regulatory repressor argR gene and overexpressing argJ gene. A genome sequence analysis indicated that the argF gene encoding ornithine carbamoyltransferase in C. glutamicum 1006 was mutated… CONTINUE READING
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