Implication of glucocorticoid receptors in the stimulation of human glioma cell proliferation by dexamethasone.

@article{Langeveld1992ImplicationOG,
  title={Implication of glucocorticoid receptors in the stimulation of human glioma cell proliferation by dexamethasone.},
  author={Cees H Langeveld and M P van Waas and Johannes C. Stoof and Win Sutanto and Edo Ronald de Kloet and John G. Wolbers and Jan J. Heimans},
  journal={Journal of neuroscience research},
  year={1992},
  volume={31 3},
  pages={524-31}
}
Dexamethasone is frequently used in the therapy of brain tumor patients. We investigated the effect of dexamethasone on the proliferation of three short-term and four established human glioma cell lines in vitro, using a microculture tetrazolium assay to determine growth rates. In one short-term culture and in one established cell line dexamethasone consistently stimulated the proliferation in a concentration-dependent way. The proliferation was maximally enhanced at a concentration of… CONTINUE READING

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