Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease.

@article{Ledesma1992ImplicationOB,
  title={Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease.},
  author={Mar{\'i}a Dolores Ledesma and Isabel Correas and Jes{\'u}s {\'A}vila and Javier D{\'i}az-Nido},
  journal={FEBS letters},
  year={1992},
  volume={308 2},
  pages={218-24}
}
Brain tau protein is phosphorylated in vitro by cdc2 and MAP2 kinases, obtained through immunoaffinity purification from rat brain extracts. The phosphorylation sites are located on the tau molecule both upstream and downstream of the tubulin-binding motifs. A synthetic peptide comprising residues 194-213 of the tau sequence, which contains the epitope recognized by the monoclonal antibody tau-1, is also efficiently phosphorylated in vitro by cdc2 and MAP2 kinases. Phosphorylation of this… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…