Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain

@article{Sasso2012ImplicationOA,
  title={Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain},
  author={Oscar Sasso and Roberto Russo and Sergio Vitiello and Giuseppina Mattace Raso and Giuseppe D'Agostino and Anna Iacono and Giovanna La Rana and Monique Vall{\'e}e and Salvatore Cuzzocrea and Pier Vincenzo Piazza and Rosaria Meli and Antonio Calignano},
  journal={PAIN},
  year={2012},
  volume={153},
  pages={33-41}
}
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Antiproliferative Effects of Palmitoylethanolamide on Human Cervical Cancer Cells
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Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease
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TLDR
Central PEA administration significantly reduced the expression of the proinflammatory enzymes cyclooxygenase-2 and inducible nitric-oxide synthase, and it significantly restored carrageenan-induced PPAR-α reduction in the spinal cord, confirming the involvement of this transcriptional factor in the control of peripheral inflammation.
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TLDR
Evidence is provided indicating the involvement of the saturated acylethanolamide PEA in ALLO synthesis through PPAR‐α in astrocytes and the antioxidative activity of this molecule is explored, confirming its homeostatic and protective role both under physiological and pathological conditions.
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TLDR
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TLDR
Findings indicate that PPAR-α mediates the anti-inflammatory effects of PEA and suggest that this fatty-acid ethanolamide may serve, like its analog OEA, as an endogenous ligand of PPar-α.
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