Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain

@article{Sasso2012ImplicationOA,
  title={Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain},
  author={O. Sasso and R. Russo and S. Vitiello and G. M. Raso and A. Calignano},
  journal={PAIN},
  year={2012},
  volume={153},
  pages={33-41}
}
Summary The role of allopregnanolone in the antinociceptive and antiallodynic effect of palmitoylethanolamide has been addressed in two models of acute and persistent pain in mice. ABSTRACT We investigated the involvement of de novo neurosteroid synthesis in the mechanisms underlying the analgesic and antihyperalgesic effects of N‐palmitoylethanolamine (PEA) in two models of acute and persistent pain, the formalin test and carrageenan‐induced paw edema. The pivotal role of peroxisome… Expand
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