Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain

  title={Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain},
  author={Oscar Sasso and Roberto Russo and Sergio Vitiello and Giuseppina Mattace Raso and Giuseppe D'Agostino and Anna Iacono and Giovanna La Rana and Monique Vall{\'e}e and Salvatore Cuzzocrea and Pier Vincenzo Piazza and Rosaria Meli and Antonio Calignano},
Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity
Ex vivo histological and molecular analysis of dorsal root ganglia, peripheral nerves and spinal cord highlighted neuroprotective effects and glia-activation prevention induced by PEA repeated administration, suggesting the usefulness of PEA in chemotherapy-induced neuropathy.
Koumine enhances spinal cord 3α-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain
This study demonstrates that 3α-HSOR is an important molecular target of koumine for alleviating neuropathic pain, and may prove a promising compound for the development of novel analgesic agents effective against intractable neuropathicPain.
Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System
Ex vivo analyses showed that PER significantly increased CB1 receptor expression and reduced inflammatory cytokines in the spinal cord and support the involvement of cannabinergic system on its mode of action.
Antiproliferative Effects of Palmitoylethanolamide on Human Cervical Cancer Cells
The data propose an additional mechanism of action of PEA, precisely the modulation of proteasome-mediated proteolysis and demonstrate that PEA can affect tumour cells survival through the activation of apoptosis.
A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration
It is reported that injections of 6-hydroxydopamine into the mouse striatum cause a local increase in NAPE and FAE levels, which precedes neuronal cell death, which point to a previously unrecognized role for NAPE-PLD in the regulation of dopamine neuron function, which may be linked to the control of NAPE homeostasis in membranes.
Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease
Chronic treatment with palmitoylethanolamide (PEA) protects against MPTP-induced neurotoxicity and the ensuing functional deficits even when administered once the insult has been initiated, and chronic PEA reversedMPTP-associated motor deficits.


Acute Intracerebroventricular Administration of Palmitoylethanolamide, an Endogenous Peroxisome Proliferator-Activated Receptor-α Agonist, Modulates Carrageenan-Induced Paw Edema in Mice
Central PEA administration significantly reduced the expression of the proinflammatory enzymes cyclooxygenase-2 and inducible nitric-oxide synthase, and it significantly restored carrageenan-induced PPAR-α reduction in the spinal cord, confirming the involvement of this transcriptional factor in the control of peripheral inflammation.
Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome‐Proliferator Activated Receptor‐α
Evidence is provided indicating the involvement of the saturated acylethanolamide PEA in ALLO synthesis through PPAR‐α in astrocytes and the antioxidative activity of this molecule is explored, confirming its homeostatic and protective role both under physiological and pathological conditions.
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.
Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo‐oxygenase systems
It is shown, for the first time, that palmitoylethanolamide has a curative effect in a model of acute inflammation, inhibiting the carrageenan‐induced oedema in a dose‐ and time‐dependent manner.
The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide
Findings indicate that PPAR-α mediates the anti-inflammatory effects of PEA and suggest that this fatty-acid ethanolamide may serve, like its analog OEA, as an endogenous ligand of PPar-α.