Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.

@article{Hirose2004ImplicationOZ,
  title={Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.},
  author={Hidenori Hirose and Kohei Arasaki and Naoshi Dohmae and Koji Takio and Kiyotaka Hatsuzawa and Masami Nagahama and Katsuko Tani and Akitsugu Yamamoto and Masaya Tohyama and Mitsuo Tagaya},
  journal={The EMBO journal},
  year={2004},
  volume={23 6},
  pages={1267-78}
}
ZW10, a dynamitin-interacting protein associated with kinetochores, is known to participate directly in turning off of the spindle checkpoint. In the present study, we show that ZW10 is located in the endoplasmic reticulum as well as in the cytosol during interphase, and forms a subcomplex with RINT-1 (Rad50-interacting protein) and p31 in a large complex comprising syntaxin 18, an endoplasmic reticulum-localized t-SNARE implicated in membrane trafficking. Like conventional syntaxin-binding… CONTINUE READING
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