Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium.

@article{Fuchs2003ImplicationOR,
  title={Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium.},
  author={S{\'e}bastien Fuchs and Josette Philippe and Pierre Corvol and Florence Pinet},
  journal={Journal of hypertension},
  year={2003},
  volume={21 2},
  pages={327-35}
}
OBJECTIVE The production of renin, which catalyzes the rate-limiting step of the renin-angiotensin system, is tightly regulated by intracellular second messengers. Among them, an increase of intracellular calcium represses renin gene expression. This inhibition of gene expression by intracellular calcium is exceptional, and the molecular mechanism supporting this phenomenon has not yet been identified. As the renin gene is negatively regulated by calcium in the same way as the parathormone (PTH… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Human apurinic/apyrimidinic endonuclease 1.

Antioxidants & redox signaling • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…