Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort

@article{Ines2014ImplicationOK,
  title={Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort},
  author={Chaar Ines and Ounissi Donia and Boughriba Rahma and Azza Ben Ammar and Amara Sameh and Taher Khalfallah and Ben hmida Abdelmajid and Mzabi Sabeh and Bouraoui S{\^a}adia},
  journal={Tumor Biology},
  year={2014},
  volume={35},
  pages={7163-7175}
}
According to the multistep route of genetic alterations in the colorectal adenoma–carcinoma sequence, the complex K-ras/p53 mutation is one of the first alterations to occur and represent an important genetic event in colorectal cancer (CRC). An evaluation of the mutation spectra in K-ras and p53 gene was effected in 167 Tunisian patients with sporadic CRC to determine whether our populations have similar pattern of genetic alteration as in Maghrebin’s population. Mutation patterns of codon 12… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 70 references

9433–8

  • Carey FA Beattie J Wilkie MJ Lightfoot TJ Coxhead J et a Smith G, p53—alternative genetic pathways to colorectal cancer. Proc Natl A 2002, 99
  • Tumor Biol.
  • 2014
1 Excerpt

helping hands to complement an active site

  • K Scheffzek, M Ahmadian, proteins Wittinghofer A. GTPase-activating
  • Trends Biochem Sci. 1998;23:257–62. 7174 Tumor…
  • 2014
1 Excerpt

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