Implication of First-Line Antiretroviral Therapy Choice on Second-Line Options

  title={Implication of First-Line Antiretroviral Therapy Choice on Second-Line Options},
  author={Seema Meloni and Chika K. Onwuamah and Oche Ochai Agbaji and Beth Chaplin and David Olufemi Olaleye and Rosemary A. Audu and Jay Osi Samuels and Oliver Chukwujekwu Ezechi and Godwin E. Imade and Adesola Z. Musa and Georgina Njideka Odaibo and Jonathan Okpokwu and Holly E. Rawizza and Muhammad A Mu’azu and Ibrahim Tijjani Dalhatu and Mukhtar Ahmed and Prosper Okonkwo and Elliot Raizes and Innocent Achanya Otobo Ujah and Chunfu Yang and Emmanuel Oni Idigbe and Phyllis J Kanki},
  booktitle={Open forum infectious diseases},
Background Although there are a number of studies comparing the currently recommended preferred and alternative first-line (1L) antiretroviral therapy (ART) regimens on clinical outcomes, there are limited data examining the impact of 1L regimen choice and duration of virologic failure (VF) on accumulation of drug resistance mutations (DRM). The patterns of… CONTINUE READING