Implication of CYP24A1 splicing in breast cancer.

  title={Implication of CYP24A1 splicing in breast cancer.},
  author={Chimi Scheible and Marc Thill and Sascha Baum and E. -F. Solomayer and Michael Friedrich},
  journal={Anti-cancer agents in medicinal chemistry},
  volume={14 1},
The expression of CYP27B1 or vitamin D 1α-hydroxylase (1α-OHase) and CYP24A1 in specific tissues may act as the central part between 25-hydroxyvitamin D [25(OH)D] serum levels and the anticancer effects of1α,25-dihydroxyvitamin D [1α,25(OH)2D3],alternative splicing of these enzymes may affect their biological functions. Here, we describe the expression of CYP24A1 and its splicing variants detected in breast cells and tissues. Manifestation of CYP24A1 mRNA was measured by RT-PCR followed by… CONTINUE READING