Implication of APP secretases in notch signaling

  title={Implication of APP secretases in notch signaling},
  author={Dieter Hartmann and Jos Tournoy and Paul Saftig and Wim Annaert and Bart de Strooper},
  journal={Journal of Molecular Neuroscience},
Signaling via notch receptors and their ligands is an evolutionary ancient and highly conserved mechanism governing cell-fate decisions throughout the animal kingdom. Upon ligand binding, notch receptors are subject to a two-step proteolysis essential for signal transduction. First, the ectodomain is removed by an enzyme cleaving near the outer-membrane surface (“site2”). Consecutively, the notch intracellular domain is liberated by a second protease cutting within the transmembrane sequence… CONTINUE READING
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