Implication of 5-HT2B receptors in the serotonin syndrome

@article{Diaz2011ImplicationO5,
  title={Implication of 5-HT2B receptors in the serotonin syndrome},
  author={Silvina L. Diaz and Luc Maroteaux},
  journal={Neuropharmacology},
  year={2011},
  volume={61},
  pages={495-502}
}

Serotonin-2B receptor antagonism increases the activity of dopamine and glutamate neurons in the presence of selective serotonin reuptake inhibition

Results indicated that 5-HT 2B receptors play, at least in part, a role in this enhancement of the therapeutic effect of aripiprazole addition to SSRIs in depression.

Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?

How these receptors may directly or indirectly control neuronal excitability in most networks involved in depression and epilepsy through interactions with the monoaminergic, GABAergic and glutamatergic neurotransmissions is illustrated.

5-HT2B receptors are required for serotonin-selective antidepressant actions

The 5-HT2B receptor appears to positively modulate serotonergic activity and to be required for the therapeutic actions of SSRIs, and should be considered as a new tractable target in the combat against depression.

Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands

Identifying brain specific molecular targets for 5-HT1A receptor ligands may result in a better targeting, raising a hope for more effective medicines for various pathologies.

Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder

5-HT 2 ligands in the treatment of anxiety and depression

This review synthesizes the current literature about the behavioral, electrophysiological and neurochemical effects of 5-HT2 receptors ligands on the monoaminergic systems but also on adult hippocampal neurogenesis to shed some light on the preclinical evidence supporting the use of 5 -HT2A and/or 5- HT2C receptor antagonists such as antipsychotics, as potential effective adjuncts in SSRIs-resistant depression.

5-HT2 ligands in the treatment of anxiety and depression

This review synthesizes the current literature about the behavioral, electrophysiological and neurochemical effects of 5-HT2 receptors ligands on the monoaminergic systems but also on adult hippocampal neurogenesis to shed some light on the preclinical evidence supporting the use of 5 -HT2A and/or 5- HT2C receptor antagonists such as antipsychotics, as potential effective adjuncts in SSRIs-resistant depression.

Animal models of the serotonin syndrome: A systematic review

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