Implication for buried polar contacts and ion pairs in hyperthermostable enzymes.

@article{Matsui2007ImplicationFB,
  title={Implication for buried polar contacts and ion pairs in hyperthermostable enzymes.},
  author={Ikuo Matsui and Kazuaki Harata},
  journal={The FEBS journal},
  year={2007},
  volume={274 16},
  pages={4012-22}
}
Understanding the structural basis of thermostability and thermoactivity, and their interdependence, is central to the successful future exploitation of extremophilic enzymes in biotechnology. However, the structural basis of thermostability is still not fully characterized. Ionizable residues play essential roles in proteins, modulating protein stability, folding and function. The dominant roles of the buried polar contacts and ion pairs have been reviewed by distinguishing between the inside… CONTINUE READING