Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.

@article{Bhati2008ImplementingTL,
  title={Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.},
  author={Mugdha Bhati and Christopher Y Lee and Amy Louise Nancarrow and Mihwa Lee and Vanessa J. Craig and Ingolf Bach and J Mitchell Guss and Joel P. Mackay and Jacqueline Mary Matthews},
  journal={The EMBO journal},
  year={2008},
  volume={27 14},
  pages={2018-29}
}
LIM-homeodomain (LIM-HD) transcription factors form a combinatorial 'LIM code' that contributes to the specification of cell types. In the ventral spinal cord, the binary LIM homeobox protein 3 (Lhx3)/LIM domain-binding protein 1 (Ldb1) complex specifies the formation of V2 interneurons. The additional expression of islet-1 (Isl1) in adjacent cells instead specifies the formation of motor neurons through assembly of a ternary complex in which Isl1 contacts both Lhx3 and Ldb1, displacing Lhx3 as… CONTINUE READING
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