Implementation of non-invasive methods in the diagnosis of diisocyanate-induced asthma.

@article{RaulfHeimsoth2013ImplementationON,
  title={Implementation of non-invasive methods in the diagnosis of diisocyanate-induced asthma.},
  author={Monika Raulf-Heimsoth and R Liebig and Boleslaw Marczynski and Gerda Borowitzki and Serge Bernard and Susanne Freundt and Evelyn Heinze and Th Br{\"u}ning and Rolf Merget},
  journal={Advances in experimental medicine and biology},
  year={2013},
  volume={788},
  pages={293-300}
}
Diisocyanate-induced asthma is difficult to diagnose since the immunopathological mechanisms and exposure determinants at the workplace are not well defined. The aim of this study was to evaluate the non-invasive methods of nasal lavage fluid (NALF) and induced sputum (IS) to enhance the diagnostic efficiency. Sixty-three diisocyanate-exposed workers with work-related shortness of breath underwent a standardized 4-steps-1-day-whole body exposure test with diisocyanates used at work up to 30 ppb… CONTINUE READING

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