Implementation of dose superimposition to introduce multiple doses for a mathematical absorption model (transit compartment model)

@article{Shen2012ImplementationOD,
  title={Implementation of dose superimposition to introduce multiple doses for a mathematical absorption model (transit compartment model)},
  author={Jun Shen and Alison Boeckmann and Andrew Vick},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2012},
  volume={39},
  pages={251-262}
}
A mathematical absorption model (e.g. transit compartment model) is useful to describe complex absorption process. However, in such a model, an assumption has to be made to introduce multiple doses that a prior dose has been absorbed nearly completely when the next dose is administered. This is because the drug input cannot be determined from drug depot compartment through integration of the differential equation system and has to be analytically calculated. We propose a method of dose… CONTINUE READING
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