Implementation of a liquid chromatography tandem mass spectrometry assay for eight adrenal C-21 steroids and pediatric reference data.

@article{Kulle2013ImplementationOA,
  title={Implementation of a liquid chromatography tandem mass spectrometry assay for eight adrenal C-21 steroids and pediatric reference data.},
  author={Alexandra E. Kulle and Maik Welzel and P. M. Holterhus and Felix G{\"u}nther Riepe},
  journal={Hormone research in paediatrics},
  year={2013},
  volume={79 1},
  pages={22-31}
}
BACKGROUND Sensitive and accurate determination of steroids is essential for diagnosing congenital and acquired adrenal diseases. Since plasma concentrations change during childhood, age-specific reference ranges are the prerequisite for clinical interpretation. The objectives of this study were to develop a sensitive and reliable method for simultaneous detection and quantification of progesterone, 17-hydroxyprogesterone, deoxycorticosterone (DOC), 11-deoxycortisol, 21-deoxycortisol… CONTINUE READING