Implementation of Linear Sensory Signaling via Multiple Coordinated Mechanisms at Central Vestibular Nerve Synapses

@article{McElvain2015ImplementationOL,
  title={Implementation of Linear Sensory Signaling via Multiple Coordinated Mechanisms at Central Vestibular Nerve Synapses},
  author={Lauren E. McElvain and Michael Faulstich and James M. Jeanne and Jeffrey D. Moore and Sascha du Lac},
  journal={Neuron},
  year={2015},
  volume={85},
  pages={1132-1144}
}
Signal transfer in neural circuits is dynamically modified by the recent history of neuronal activity. Short-term plasticity endows synapses with nonlinear transmission properties, yet synapses in sensory and motor circuits are capable of signaling linearly over a wide range of presynaptic firing rates. How do such synapses achieve rate-invariant transmission despite history-dependent nonlinearities? Here, ultrastructural, biophysical, and computational analyses demonstrate that concerted… CONTINUE READING
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