Implementation of High Resolution Whole Genome Array CGH in the Prenatal Clinical Setting: Advantages, Challenges, and Review of the Literature

@inproceedings{Evangelidou2013ImplementationOH,
  title={Implementation of High Resolution Whole Genome Array CGH in the Prenatal Clinical Setting: Advantages, Challenges, and Review of the Literature},
  author={Paola Evangelidou and Angelos Alexandrou and Maria Moutafi and Marios Ioannides and Pavlos Antoniou and George Koumbaris and Ioannis Kallikas and Voula Velissariou and Carolina Sismani and Philippos C. Patsalis},
  booktitle={BioMed research international},
  year={2013}
}
Array Comparative Genomic Hybridization analysis is replacing postnatal chromosomal analysis in cases of intellectual disabilities, and it has been postulated that it might also become the first-tier test in prenatal diagnosis. In this study, array CGH was applied in 64 prenatal samples with whole genome oligonucleotide arrays (BlueGnome, Ltd.) on DNA extracted from chorionic villi, amniotic fluid, foetal blood, and skin samples. Results were confirmed with Fluorescence In Situ Hybridization or… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Microarrays in prenatal diagnosis.

Best practice & research. Clinical obstetrics & gynaecology • 2017

Cell-free DNA testing: inadequate implementation of an outstanding technique.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology • 2015

References

Publications referenced by this paper.
Showing 1-10 of 47 references

and L

J. Coppinger, S. Alliman, A. N. Lamb, B. S. Torchia, B. A. Bejjani
G. Shaffer, “Whole-genome microarray analysis in prenatal specimens identifies clinically significant chromosome alterations without increase in results of unclear significance compared to targeted microarray,” Prenatal Diagnosis, vol. 29, no. 12, pp. 1156–1166 • 2009
View 5 Excerpts
Highly Influenced

Foetal genetic diagnosis: development of techniques for early sampling of foetal cells.

Acta pathologica et microbiologica Scandinavica • 1968
View 4 Excerpts
Highly Influenced

B

R. J. Wapner, C. L. Martin
Levy et al., “Chromosomal microarray versus karyotyping for prenatal diagnosis,”TheNew England Journal of Medicine, vol. 367, no. 23, pp. 2175–2184 • 2012
View 1 Excerpt

C

W. Dondorp, B. Sikkema-Raddatz
de Die-Smulders, and G. de Wert, “Arrays in postnatal and prenatal diagnosis: an exploration of the ethics of consent,” Human Mutation, vol. 33, no. 6, pp. 916–922 • 2012
View 1 Excerpt

N

B. A. Nowakowska
de Leeuw, C. A. Ruivenkamp et al., “Parental insertional balanced translocations are an important cause of apparently de novoCNVs in patientswith developmental anomalies,” European Journal of Human Genetics, vol. 20, no. 2, pp. 166–170 • 2012
View 2 Excerpts

Similar Papers

Loading similar papers…