Implementation of High Resolution Whole Genome Array CGH in the Prenatal Clinical Setting: Advantages, Challenges, and Review of the Literature

  title={Implementation of High Resolution Whole Genome Array CGH in the Prenatal Clinical Setting: Advantages, Challenges, and Review of the Literature},
  author={Paola Evangelidou and Angelos Alexandrou and Maria Moutafi and Marios Ioannides and Pavlos Antoniou and George Koumbaris and Ioannis Kallikas and Voula Velissariou and Carolina Sismani and Philippos C. Patsalis},
  booktitle={BioMed research international},
Array Comparative Genomic Hybridization analysis is replacing postnatal chromosomal analysis in cases of intellectual disabilities, and it has been postulated that it might also become the first-tier test in prenatal diagnosis. In this study, array CGH was applied in 64 prenatal samples with whole genome oligonucleotide arrays (BlueGnome, Ltd.) on DNA extracted from chorionic villi, amniotic fluid, foetal blood, and skin samples. Results were confirmed with Fluorescence In Situ Hybridization or… CONTINUE READING
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