Implausibility of the vibrational theory of olfaction.

@article{Block2015ImplausibilityOT,
  title={Implausibility of the vibrational theory of olfaction.},
  author={Eric Block and Seogjoo J. Jang and Hiroaki Matsunami and Sivakumar Sekharan and B{\'e}r{\'e}nice Dethier and Mehmed Z Ertem and Sivaji Gundala and Yi Pan and Shengju Li and Zhen Li and Stephene N Lodge and Mehmet Ozbil and Huihong Jiang and Sonia F Penalba and Victor S Batista and Hanyi Zhuang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 21},
  pages={E2766-74}
}
The vibrational theory of olfaction assumes that electron transfer occurs across odorants at the active sites of odorant receptors (ORs), serving as a sensitive measure of odorant vibrational frequencies, ultimately leading to olfactory perception. A previous study reported that human subjects differentiated hydrogen/deuterium isotopomers (isomers with isotopic atoms) of the musk compound cyclopentadecanone as evidence supporting the theory. Here, we find no evidence for such differentiation at… CONTINUE READING
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