Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study.

@article{Stadelmann2008ImplantsDB,
  title={Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study.},
  author={Vincent A. Stadelmann and Olivier Gauthier and Alexandre Terrier and Jean Michel Bouler and Dominique P. Pioletti},
  journal={European cells & materials},
  year={2008},
  volume={16},
  pages={10-6}
}
It is a clinical challenge to obtain a sufficient orthopaedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. Bisphosphonate can be used to prevent the osteoclastic response, but when administered systemically its bioavailability is low and the time it takes for the drug to reach the periprosthetic bone may be a limiting factor. Recent data has shown… CONTINUE READING

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