Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines.

@article{Kamihata2001ImplantationOB,
  title={Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines.},
  author={Hiroshi Kamihata and Hiroaki Matsubara and Takashi Nishiue and Soichiro Fujiyama and Yoshiaki Tsutsumi and Ryoji Ozono and Hisao Masaki and Yasukiyo Mori and Osamu Iba and Eriko Tateishi and Atsushi Kosaki and Satoshi Shintani and Toyoaki Murohara and Takahiro Imaizumi and Toshiji Iwasaka},
  journal={Circulation},
  year={2001},
  volume={104 9},
  pages={1046-52}
}
BACKGROUND Bone marrow implantation (BMI) was shown to enhance angiogenesis in a rat ischemic heart model. This preclinical study using a swine model was designed to test the safety and therapeutic effectiveness of BMI. METHODS AND RESULTS BM-derived mononuclear cells (BM-MNCs) were injected into a zone made ischemic by coronary artery ligation. Three weeks after BMI, regional blood flow and capillary densities were significantly higher (4.6- and 2.8-fold, respectively), and cardiac function… CONTINUE READING
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Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.

Proceedings of the National Academy of Sciences of the United States of America • 2000

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