Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring.

@article{Syedain2011ImplantableAG,
  title={Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring.},
  author={Zeeshan H Syedain and Lee A. Meier and Jason W Bjork and A Lee and Robert T. Tranquillo},
  journal={Biomaterials},
  year={2011},
  volume={32 3},
  pages={714-22}
}
Tissue-engineered arteries based on entrapment of human dermal fibroblasts in fibrin gel yield completely biological vascular grafts that possess circumferential alignment characteristic of native arteries and essential to their mechanical properties. A bioreactor was developed to condition six grafts in the same culture medium while being subjected to similar cyclic distension and transmural flow resulting from pulsed flow distributed among the graft lumens via a manifold. The lumenal pressure… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

Engineering Vessels as Good as New?

JACC. Basic to translational science • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Effects of biaxial stretch on arteriolar function in vitro.

American journal of physiology. Heart and circulatory physiology • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…