Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.

@article{Schwartz1999ImplantSC,
  title={Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.},
  author={Zvi Schwartz and Christoph H. Lohmann and J Oefinger and Lynda F. Bonewald and David D. Dean and Barbara D Boyan},
  journal={Advances in dental research},
  year={1999},
  volume={13},
  pages={38-48}
}
This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased… CONTINUE READING

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