Implant pellets I: effects of compression pressure on in vivo dissolution of delmadinone acetate pellets.

@article{Kent1976ImplantPI,
  title={Implant pellets I: effects of compression pressure on in vivo dissolution of delmadinone acetate pellets.},
  author={J. Christopher Kent},
  journal={Journal of pharmaceutical sciences},
  year={1976},
  volume={65 1},
  pages={
          89-92
        }
}
A formulation containing 95% delmadinone acetate was compressed at three different pressures. These pressures resulted in a pellet density difference of 19%. In vivo dissolution profiles were determined for five lots of pellets. The pellets were implanted subcutaneously in rats, removed periodically, and assayed chemically for remaining steroid. The resulting data were fit, using the computer program NONLIN, to a dissolution model. The dissolution rate for the lot with the lowest density made… CONTINUE READING
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