Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade.

@article{Zheng2016ImperatorinEA,
  title={Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade.},
  author={Yi Mei Zheng and Amy Xiaoxu Lu and James Zheng Shen and Amy Ho Yan Kwok and Wing Shing Ho},
  journal={Oncology reports},
  year={2016},
  volume={35 4},
  pages={
          1995-2002
        }
}
Despite advances in medical treatments for colon cancer, it remains one of the leading causes of cancer-related mortality among men. Thus, more efficacious treatment strategies for colon cancer are needed. Imperatorin is one of the major ingredients present in the root of Angelica dahurica, and has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. However, the medical properties of imperatorin remain unclear. In the present study, the anti… 
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Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects
TLDR
This review addresses different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors and their potential efficacy and safety as a cancer lessening agents.
Imperatorin shows selective antitumor effects in SGC-7901 human gastric adenocarcinoma cells by inducing apoptosis, cell cycle arrest and targeting PI3K/Akt/m-TOR signalling pathway.
  • J. Am, W. Gong, Y. Su, Z. Mou
  • Biology, Chemistry
    Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • 2017
TLDR
Imperatorin could prove an important lead molecule for the treatment of gastric cancer and deserves further research in vivo against more cell lines.
Imperatorin as a Promising Chemotherapeutic Agent against Human Larynx Cancer and Rhabdomyosarcoma Cells
TLDR
Imperatorin (IMP) exhibited the most potent growth inhibitory effects against human rhabdomyosarcoma and larynx cancer cell lines owing to inhibition of the cell cycle progression connected with specific changes in gene expression, including CDKN1A.
Imperatorin: A review of its pharmacology, toxicity and pharmacokinetics.
Effects of imperatorin in the cardiovascular system and cancer.
Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo
  • Minchao Lv, Q. Xu, +5 authors Wei Wang
  • Biology, Medicine
    Cancer cell international
  • 2021
TLDR
It is revealed that imperatorin induced autophagy and cell cycle arrest through PTEN-PI3K-AKT-mTOR/p21 signaling pathway by targeting and up-regulating PTEN in human osteosarcoma cells, and is a desirable candidate for clinical treatments of osteosARcoma.
Apoptosis effects of imperatorin on synoviocytes in rheumatoid arthritis through mitochondrial/caspase-mediated pathways.
TLDR
IPT inhibits cell proliferation and induces apoptosis in RA-FLSs that may be associated with mitochondrial/caspase-mediated signalling pathways, and in vivo studies showed that IPT not only significantly reduced the collagen induced arthritis by reducing synovial hyperplasia, and pannus formation but also enhanced the apoptotic index of ankle joint cells.
Effect of Juice and Extracts from Saposhnikovia divaricata Root on the Colon Cancer Cells Caco-2
TLDR
Juice and this extract exhibited the protective properties in relation to the cell membranes and they induced apoptosis and the knowledge of further mechanisms of anticancer activity of the examined products will allow to consider their use as part of combination therapy.
Design, synthesis and in vitro evaluation of coumarin–imidazo[1,2-a]pyridine derivatives against cancer induced osteoporosis
TLDR
The ability of coumarin–imidazo[1,2-a]pyridine hybrids to reverse the negative impact of MDA-MB-231 cancer cells on osteoblast differentiation is investigated and illustrates the potential of designed hybrids to re-establish the bone homeostasis.
A novel sight of the primary active compounds from Umbelliferae: focusing on mitochondria
TLDR
A promising drug-designing strategy is proposed, mitochondria-targeted drugs referring to natural compounds of Umbelliferae that themselves are able to improve the mitochondrial environment.
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References

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TLDR
The data demonstrate that limonin and imperatorin have anticancer potential which is associated with promoting cell apoptosis through expression of apoptosis-related proteins.
Antiproliferative Effect of Furanocoumarins from the Root of Angelica dahurica on Cultured Human Tumor Cell Lines
TLDR
A bioassay‐guided fractionation of the root extract of Angelica dahurica led to the isolation of six furanocoumarins as active ingredients responsible for the antitumoral property, which exhibited a signicant inhibition on cell proliferation in a dose‐dependent manner.
Imperatorin Inhibits HIV-1 Replication through an Sp1-dependent Pathway*
TLDR
It is reported that imperatorin inhibits either vesicular stomatitis virus-pseudotyped or gp160-enveloped recombinant HIV-1 infection in several T cell lines and in HeLa cells, highlighting the potential of Sp1 transcription factor as a target for natural anti-HIV-1 compounds such as furanocoumarins that might have a potential therapeutic role in the management of AIDS.
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TLDR
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TLDR
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TLDR
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