Impediments to replication fork movement: stabilisation, reactivation and genome instability

@article{Lambert2013ImpedimentsTR,
  title={Impediments to replication fork movement: stabilisation, reactivation and genome instability},
  author={Sarah A. E. Lambert and Antony M Carr},
  journal={Chromosoma},
  year={2013},
  volume={122},
  pages={33-45}
}
Maintaining genome stability is essential for the accurate transmission of genetic material. Genetic instability is associated with human genome disorders and is a near-universal hallmark of cancer cells. Genetic variation is also the driving force of evolution, and a genome must therefore display adequate plasticity to evolve while remaining sufficiently stable to prevent mutations and chromosome rearrangements leading to a fitness disadvantage. A primary source of genome instability are… CONTINUE READING
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