[Impedance effects of interleukin-6 on cyclophosphamide-induced hematopoietic damnification in dogs].

Abstract

The aim of this study is to evaluate the effect of Interleukin-6 on cyclophosphamide-induced hematopoietic damnification. The doses of Interleukin-6 in 3 different regimens were hypodermally injected into dogs for 7 days respectively to establish the cyclophosphamide-induced hematopoietic damnification model. The effect of Interleukin-6 on the production of platelets and the amount of other cells in the dogs' bone marrow were determined on the 21st day. The results showed that Interleukin-6 significantly alleviated the reduction of platelet count and recovered the platelets level faster. The impedance effects of Interleukin-6 directed against hematopoietic damnification of bone marrow and spleen were shown by pathological examination. These suggest that the Interleukin-6 can significantly impede cyclophosphamide-induced hematopoietic damnification.

Cite this paper

@article{Yin2005ImpedanceEO, title={[Impedance effects of interleukin-6 on cyclophosphamide-induced hematopoietic damnification in dogs].}, author={Hailin Yin and Xueling He and Xu Bao and Xuexu Liu and Guangwu Yang}, journal={Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi}, year={2005}, volume={22 4}, pages={798-801} }