Impairs Angiogenesis NEU 1 Sialidase Regulates the Sialylation State of CD 31 and Disrupts CD 31-Driven Capillary-Like Tube Formation in Human Lung Microvascular

@inproceedings{Lee2014ImpairsAN,
  title={Impairs Angiogenesis NEU 1 Sialidase Regulates the Sialylation State of CD 31 and Disrupts CD 31-Driven Capillary-Like Tube Formation in Human Lung Microvascular},
  author={Chunsik Lee and Anguo Liu and Alba Miranda-Ribera and Sang Won Hyun and Erik Peter Lillehoj and Alan S. Cross and Antonino Passaniti and P Richard Grimm and Bo-young Kim and Paul A. Welling and Joseph A. Madri and Horace M. Delisser and Simeon E. Goldblum},
  year={2014}
}
The highly sialylated vascular endothelial surface undergoes changes in sialylation upon adopting the migratory/angiogenic phenotype. We recently established endothelial cell (EC) expression of NEU1 sialidase (Cross, AS et al; J Biol Chem 287:15966-15980, 2012). We asked whether NEU1 might regulate EC capillary-like tube formation on a Matrigel substrate. In human pulmonary microvascular EC (HPMEC)s, prior silencing of NEU1 did not alter tube formation. Infection of HPMECs with increasing MOIs… CONTINUE READING