Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats

@article{Clausen2011ImpairmentsOE,
  title={Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats},
  author={Bettina Clausen and Todd R Schachtman and Louise T. Mark and Mette Reinholdt and Gert R. J. Christoffersen},
  journal={Behavioural Brain Research},
  year={2011},
  volume={223},
  pages={241-254}
}
D1-receptor antagonism is known to impair rodent memory but also inhibits spontaneous exploration of stimuli to be remembered. Hypo-exploration could contribute to impaired memory by influencing event processing. In order to explore this effect, the D1 receptor antagonist, SCH23390, was administered to rats via routes that either did or did not affect spontaneous exploration: systemic or prelimbic administration, respectively. Effects were tested in spatial and non-spatial memory tasks selected… CONTINUE READING

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