Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease

@article{Mably2017ImpairmentsIS,
  title={Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease},
  author={Alexandra J Mably and Brian J. Gereke and D. T. Jones and Laura Lee Colgin},
  journal={Hippocampus},
  year={2017},
  volume={27}
}
Alzheimer's disease (AD) is an irreversible and highly progressive neurodegenerative disease. Clinically, patients with AD display impairments in episodic and spatial memory. However, the underlying neuronal dysfunctions that result in these impairments remain poorly understood. The hippocampus is crucial for spatial and episodic memory, and thus we tested the hypothesis that abnormal neuronal representations of space in the hippocampus contribute to memory deficits in AD. To test this… Expand
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