Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice.

@article{PozzoMiller1999ImpairmentsIH,
  title={Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice.},
  author={Lucas Pozzo-Miller and Wolfram Gottschalk and Lian Cheng Zhang and K L McDermott and Jianhua Du and R. K. Gopalakrishnan and Chikara Oho and Z H Sheng and B. F. Lu},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 12},
  pages={
          4972-83
        }
}
Brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) at hippocampal CA1 synapses by a presynaptic enhancement of synaptic transmission during high-frequency stimulation (HFS). Here we have investigated the mechanisms of BDNF action using two lines of BDNF knockout mice. Among other presynaptic impairments, the mutant mice exhibited more pronounced synaptic fatigue at CA1 synapses during high-frequency stimulation, compared with wild-type animals. Quantitative analysis… CONTINUE READING

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