Impairments in brain-to-blood transport of amyloid-β and reabsorption of cerebrospinal fluid in an animal model of Alzheimer's disease are reversed by antisense directed against amyloid-β protein precursor.

@article{Banks2011ImpairmentsIB,
  title={Impairments in brain-to-blood transport of amyloid-β and reabsorption of cerebrospinal fluid in an animal model of Alzheimer's disease are reversed by antisense directed against amyloid-β protein precursor.},
  author={W. A. Banks and V B Sameer Kumar and Susan A. Farr and Ryota Nakaoke and S. M. Robinson and J Eileen Morley},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={23 4},
  pages={599-605}
}
The blood-brain barrier (BBB) influences brain levels of amyloid-β (Aβ) by transporting Aβ out of the brain (efflux) and by the reabsorption of cerebrospinal fluid (CSF) into the blood stream (bulk flow). In Alzheimer's disease (AD) and normal aging, unknown factors impair Aβ efflux and bulk flow in aging and in AD. These impairments have been proposed as mechanisms by which the Aβ burden in brain can increase. Impairment in Aβ efflux occurs in animal models of AD, including the aged SAMP8… CONTINUE READING

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The blood - brain barrier ( BBB ) influences brain levels of amyloid-β ( Aβ ) by transporting Aβ out of the brain ( efflux ) and by the reabsorption of cerebrospinal fluid ( CSF ) into the blood stream ( bulk flow ) .
The blood - brain barrier ( BBB ) influences brain levels of amyloid-β ( Aβ ) by transporting Aβ out of the brain ( efflux ) and by the reabsorption of cerebrospinal fluid ( CSF ) into the blood stream ( bulk flow ) .
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