Impairments in Brain-to-Blood Transport of Amyloid-and Reabsorption of Cerebrospinal Fluid in an Animal Model of Alzheimer ’ s Disease are Reversed by Antisense Directed Against Amyloid-Protein Precursor

  • William A. Banksa, Vijaya B. Kumarb, Susan A. Farrb, Ryota Nakaokec, Sandra M. Robinsonb, John E. Morleyb
  • Published 2011


The blood-brain barrier (BBB) influences brain levels of amyloid(A ) by transporting A out of the brain (efflux) and by the reabsorption of cerebrospinal fluid (CSF) into the blood stream (bulk flow). In Alzheimer’s disease (AD) and normal aging, unknown factors impair A efflux and bulk flow in aging and in AD. These impairments have been proposed as… (More)

2 Figures and Tables


  • Presentations referencing similar topics