Impairments in Brain-Derived Neurotrophic Factor-Induced Glutamate Release in Cultured Cortical Neurons Derived from Rats with Intrauterine Growth Retardation: Possible Involvement of Suppression of TrkB/Phospholipase C-γ Activation

@article{Numakawa2014ImpairmentsIB,
  title={Impairments in Brain-Derived Neurotrophic Factor-Induced Glutamate Release in Cultured Cortical Neurons Derived from Rats with Intrauterine Growth Retardation: Possible Involvement of Suppression of TrkB/Phospholipase C-γ Activation},
  author={Tadahiro Numakawa and Tomoya Matsumoto and Yoshiko Ooshima and Shuichi Chiba and Miyako Furuta and Aiko Izumi and Midori Ninomiya-Baba and Haruki Odaka and Kazuo Hashido and Naoki Adachi and Hiroshi Kunugi},
  journal={Neurochemical Research},
  year={2014},
  volume={39},
  pages={785-792}
}
Low birth weight due to intrauterine growth retardation (IUGR) is suggested to be a risk factor for various psychiatric disorders such as schizophrenia. It has been reported that developmental cortical dysfunction and neurocognitive deficits are observed in individuals with IUGR, however, the underlying molecular mechanisms have yet to be elucidated. Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are associated with schizophrenia and play a role in cortical development. We… CONTINUE READING
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