Impairment of vertical saccades from an acute pontine lesion in multiple sclerosis.

@article{Rufa2008ImpairmentOV,
  title={Impairment of vertical saccades from an acute pontine lesion in multiple sclerosis.},
  author={Alessandra Rufa and Alfonso Cerase and Lorenzo De Santi and Marco Mandal{\`a} and Daniele Nuti and Antonio Giorgio and Pasquale Annunziata},
  journal={Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society},
  year={2008},
  volume={28 4},
  pages={
          305-7
        }
}
  • A. Rufa, A. Cerase, +4 authors P. Annunziata
  • Published 1 December 2008
  • Medicine, Psychology
  • Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
A 62-year-old woman with relapsing-remitting multiple sclerosis suddenly complained of diplopia associated with bilateral adduction impairment, nystagmus of the abducting eye bilaterally, and sparing of abduction, convergence, and vertical eye movements, consistent with bilateral internuclear ophthalmoplegia. Within 1 week, she had developed a complete horizontal gaze paralysis even with the oculocephalic maneuver. Vertical saccades were slow and convergence was preserved. There was a right… 
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Nuclear, internuclear, and supranuclear ocular motor disorders.
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The brainstem anatomy and physiology of the brainstem saccade-generating network is discussed, with an emphasis on insights from quantitative ocular motor recordings; the clinical features of SGPs are discussed; and the broad differential diagnosis ofSGPs is considered.
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The case of a 15-year-old patient who presented with diplopia due to unilateral 6th nerve palsy as the first manifestation of multiple sclerosis is reported.
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Eye movement abnormalities of supranuclear origin are characterized by gaze palsies, tonic gaze deviation, saccadic and smooth pursuit disorders, vergence abnormalities, nystagmus, and ocular oscillations.
Binocular, Accommodative and Oculomotor Alterations In Multiple Sclerosis: A Review
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Oculomotor impairment is a common component of disability in MS patients and should be considered when managing this type of patients, and accommodative, vergence and stereopsis alterations have not been comprehensively studied despite their relevance.
Optic disc edema and optic nerve head drusen.
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The most recent MRI, 1.5 years after the onset of symptoms, revealed an increase in number and extent of the white matter hyperintensities and Glatiramer acetate therapy was initiated.
Translational Neurology of Slow Saccades
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Insight into saccadic dysfunction from nonhuman basic science research is summarized and advances from translational research in common and uncommon human central neurological disease states that lead to vertical and/or horizontal saccade slowing are reviewed.
Towards understanding ocular motility: III, IV and VI.
Eye movement abnormalities.
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This review summarizes the most representative EMAs from the supratentorial level to the brainstem, finding that the most complex EMAs are due to midbrain stroke.
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References

SHOWING 1-10 OF 12 REFERENCES
Complete bilateral horizontal gaze paralysis disclosing multiple sclerosis
TLDR
Improvement first involved the adduction movements in both eyes, whereas bilateral abduction paresis still persisted for a few weeks, before complete recovery of eye movements, following a similar progression as at the onset.
The clinical spectrum of internuclear ophthalmoplegia in multiple sclerosis.
The eye movements of 100 patients with multiple sclerosis were examined clinically, including a saccade test. Thirty-four cases of internuclear ophthalmoplegia were found, of which 14 were bilateral…
Unusual ocular motor findings in multiple sclerosis
Ocular motor consequences of damage to the abducens nucleus area in humans.
A patient with a complete unilateral conjugate gaze paralysis caused by a small lesion affecting the region of the right abducens nucleus, documented by magnetic resonance imaging, is reported. Eye…
The neuro-ophthalmology of multiple sclerosis
Vertical vestibulo-ocular reflex, smooth pursuit and eye-head tracking dysfunction in internuclear ophthalmoplegia.
TLDR
The results indicate that the medial longitudinal fasciculi or neighbouring tegmental tracts convey bidirectional signals for vertical pursuit, cancellation, and vestibular smooth eye movements in man, and that smooth pursuit and cancellation of the VOR can be dissociated in INO.
Saccadic premotor neurons in the brainstem: functional neuroanatomy and clinical implications
TLDR
The localization of some premotor saccadic neurons in human brain and their neurochemistry are described, based on monkey data.
Vertical glaze paralysis and the rostral interstitial nucleus of the medial longitudinal fasciculus.
TLDR
Reconstructions of lesions in patients with different types of vertical gaze paralysis show that destruction of the rostral interstitial nucleus of the MLF bilaterally leads to an impairment of fast vertical eye movements and it is proposed that the nucleus participates in the production of vertical saccades and quick phases of nystagmus in man.
Effect of ibotenic acid lesions of the omnipause neurons on saccadic eye movements in rhesus macaques.
  • C. Kaneko
  • Psychology, Biology
    Journal of neurophysiology
  • 1996
TLDR
To test the validity of competing models of the pontine saccade generator, neurotoxic lesions were made in the nucleus raphe interpositus (rip), which contains one of the principal types of saccades-related neurons, the omnipause neurons (OPNs).
What clinical disorders tell us about the neural control of saccadic eye movements.
...
1
2
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