Impairment of the plasmin activation system in primary pulmonary hypertension: evidence for gender differences.

@article{Christ2001ImpairmentOT,
  title={Impairment of the plasmin activation system in primary pulmonary hypertension: evidence for gender differences.},
  author={Guenter Christ and Senta Graf and Renate Huber-Beckmann and Gerlinde Zorn and Ir{\'e}ne Lang and M Kneussi and Bernd R. Binder and Kurt Huber},
  journal={Thrombosis and haemostasis},
  year={2001},
  volume={86 2},
  pages={557-62}
}
Primary pulmonary hypertension (PPH) is a rare disorder, with marked in-situ thrombosis of small pulmonary vessels occurring primarily in adult women. We investigated whether differences in the plasmin- and thrombin activation system are associated with the predominate affection of females. Plasma levels of plasminogen activator inhibitor type 1 (PAI-1), tissue-type plasminogen activator (t-PA), fibrinogen, thrombin-antithrombin (TAT) complexes, and prothrombin fragments (F1.2) were measured at… CONTINUE READING