Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents.

@article{Ferrier2006ImpairmentOT,
  title={Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents.},
  author={Laurent P. Ferrier and Florian B{\'e}rard and Laurent Debrauwer and Chantal Chabo and Philippe Langella and Lionel Bu{\'e}no and Jean Fioramonti},
  journal={The American journal of pathology},
  year={2006},
  volume={168 4},
  pages={1148-54}
}
Alcohol hepatic toxicity in heavy drinkers is associated with high endotoxin blood levels and increased intestinal permeability. Because endotoxins can cross damaged mucosa, we investigated the mechanisms through which ethanol impairs the colonic epithelium of rats submitted to acute alcohol intake. Colonic permeability to (51)Cr-ethylenediamintetraacetic acid was increased 24 hours after 3.0 g/kg ethanol intake (3.2 +/- 0.2% versus 2.2 +/- 0.2%) and was associated with significant endotoxemia… CONTINUE READING

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