Impairment of slow inactivation as a common mechanism for periodic paralysis in DIIS4-S5

@article{Bendahhou2002ImpairmentOS,
  title={Impairment of slow inactivation as a common mechanism for periodic paralysis in DIIS4-S5},
  author={Saı̈d Bendahhou and Theodore R. Cummins and Roger W. Kula and Y.-H. Fu and Louis J. Pt{\'a}{\vc}ek},
  journal={Neurology},
  year={2002},
  volume={58},
  pages={1266-1272}
}
Background Mutations in the human skeletal muscle sodium channels are associated with hyperKPP, hypoKPP, paramyotonia congenita, and potassium-aggravated myotonia. This article describes the clinical manifestations of a patient with hyperKPP carrying a mutation (L689I) occurring in the linker DIIS4-S5 and its functional expression in a mammalian system. Objective To correlate the clinical manifestations of hyperkalemic periodic paralysis (hyperKPP) with the functional expression of a sodium… Expand
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