Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task

Local injection of substance P (SP)-saporin can cause selective ablation of striatal interneurons expressing SP receptors (SPR). In this study, we evaluated quantitatively the impairment of skilled forelimb use after unilateral ablation of the striatal interneurons using a pasta matrix reaching task in rats. We found a significant decrease of the number of… (More)