Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

@article{Fine1990ImpairmentOP,
  title={Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin.},
  author={Jay S. Fine and Allen E. Silverstone and Thomas A Gasiewicz},
  journal={Journal of immunology},
  year={1990},
  volume={144 4},
  pages={
          1169-76
        }
}
Exposure of experimental animals to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) results in severe thymic atrophy and suppression of cell-mediated and humoral immune functions. However, despite much effort the mechanism by which TCDD produces these responses, particularly thymic atrophy, remains unclear. In this report, we have examined the effect of acute TCDD exposure on lymphocyte stem cells in young adult BALB/c mice to determine whether alterations to events early in T lymphopoiesis… CONTINUE READING

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