Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia.

@article{Brewer2003ImpairmentOO,
  title={Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia.},
  author={W. Brewer and S. Wood and P. McGorry and S. Francey and L. Phillips and A. Yung and V. Anderson and D. Copolov and Bruce S. Singh and D. Velakoulis and C. Pantelis},
  journal={The American journal of psychiatry},
  year={2003},
  volume={160 10},
  pages={
          1790-4
        }
}
OBJECTIVE Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset. METHOD The olfactory identification ability of 81 patients at ultra-high risk for psychosis was examined in relation to that of 31 healthy comparison subjects. Twenty-two of the ultra-high-risk patients (27.2%) later became psychotic, and 12 of these were diagnosed with a… Expand
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TLDR
Testing olfaction is simple and inexpensive, and could provide clinically valuable information at first episode to identify those patients who might benefit from more intensive interventions promoting functional recovery. Expand
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The results suggest that impaired OI is not a good marker of the onset of psychosis and schizophrenia, but may differentiate UHR individuals who experience a poor functional outcome, regardless of transition status. Expand
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TLDR
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Olfactory processing in schizophrenia, non-ill first-degree family members, and young people at-risk for psychosis
  • Vidyulata Kamath, B. Turetsky, +6 authors P. Moberg
  • Psychology, Medicine
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2014
TLDR
The data suggest that odor identification impairment, in isolation, may represent a genetic marker of vulnerability for schizophrenia, while odor discrimination deficits may be a biomarker associated with the development of psychosis. Expand
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TLDR
UPSIT scores can be used to identify patients at risk for persistent negative and disorganized/cognitive symptoms and patients with nonremission of negative and cognitive/disorganized symptoms had significantly lower baseline UPSIT scores compared with patients with remission. Expand
Olfactory deficits in individuals at risk for psychosis and patients with schizophrenia: relationship with socio-cognitive functions and symptom severity
TLDR
It is suggested that high-risk subjects for psychosis already show odor identification deficits similar to those observed in schizophrenia patients, which probably reflect a biological trait related to vulnerability to psychosis. Expand
Olfactory deficits, cognition and negative symptoms in early onset psychosis
TLDR
Smell identification deficits are a characteristic of early onset psychosis that may be useful for prognostic purposes and were specifically related to typical characteristics of schizophrenia, such as negative symptoms and lower intelligence, but not to features of bipolar disorder,such as grandiosity. Expand
Olfactory Functioning in First-Episode Psychosis
TLDR
Findings indicate that olfactory deficits extend beyond measures of odor identification in FEP with greater deficits observed in schizophrenia-related subgroups of psychosis. Expand
Olfactory identification in young relatives at risk for schizophrenia
TLDR
The potential value of OID deficits as markers of psychopathological vulnerability in young relatives at risk for schizophrenia deserves further investigation. Expand
[Olfactory dysfunctions in patients with schizophrenia].
TLDR
Olfactory dysfunctions in patients with schizophrenia are becoming the aim of an increased number of studies, but it is difficult to use olfactory deficits as endophenotypical markers of schizophrenia, and further studies are necessary. Expand
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