Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation.

@article{Jobim2012ImpairmentOO,
  title={Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation.},
  author={Paulo Fernandes Costa Jobim and Thiago R. Pedroso and Aline Werenicz and Raissa R. Christoff and Natasha Maurmann and Gustavo Kellermann Reolon and Nadja Schr{\"o}der and Rafael Roesler},
  journal={Behavioural brain research},
  year={2012},
  volume={228 1},
  pages={151-8}
}
The role of the basolateral complex of the amygdala (BLA) in recognition memory remains poorly understood. The mammalian target of rapamycin (mTOR) in the BLA and other brain areas has been implicated in synaptic plasticity and memory. We have recently shown that mTOR signaling in both the BLA and the dorsal hippocampus (DH) is required for formation and reconsolidation of inhibitory avoidance, a fear-motivated memory task. Here we examined the effects of infusions of the mTOR inhibitor… CONTINUE READING